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Gene Regulation in Cancer and Development 694:492
Spring 2008

Lecture: M2, Th2
10:20-11:40
Nelson Hall Rm A237


 

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Course Coordinator:
Dr. Ken Irvine
Course Instructors:
Dr. Ken Irvine
Dr. Ruth Steward
Dr. Eileen White

Gene Regulation in Cancer and Development (01:694:492) is a course for advanced undergraduate students majoring in the Life Sciences.  Molecular biology is an experimental science, and a major goal of this course is to explain not just what molecular biologists know, but how they know it.  Thus, while covering selected topics in gene regulation, development, and cancer, we will emphasize the methods, experimental design, history, and deductive reasoning that has led to the current state of understanding of these topics.

The course will be taught by three faculty members from the Department of Molecular Biology and Biochemistry.  Each faculty member will give ~8 lectures.  Because we are focusing on current topics, there is no textbook, but there will be assigned readings and literature research from the primary literature, and where appropriate, background reference material will be recommended by the instructors. 

There will be three exams over the semester that will cover the material presented in class; there will not be a cumulative final exam.  Each exam will count for 25% of the grade.  In addition, there will be problem sets, in class quizzes, and/or other assignments that together will count for the remaining 25% of the grade.  Absence from exams will be excused only in the case of serious illness or family emergency, and only when backed up by appropriate documentation.  Requests for regrades must be submitted within 72 hours of return of the exam.

Date Instructor Topic
Jan. 24 Irvine Course Introduction & Review of some Fundamental Concepts in Molecular Biology
Jan. 28 Steward Drosophila as a model system:  genetics and development
Jan. 31 Steward Cloning genes in Drosophila:  basic techniques
Feb 4 Steward

Cloning genes in Drosophila:  enhancer trap, walking along the chromosome, transformation rescue First problem set handed out

Feb. 7 Steward Genomics and micro RNAs
Feb 11 Steward

Control of gene expression in development:  activated and repressed promoters
First Problem Set Due

Feb. 14 Gabriel Basics of Cancer Biology
Feb 18 Gabriel Tumor Viruses and Oncogenes
Feb 21 Gabriel

Tumor Suppressors Second problem set handed out

Feb 25 Gabriel

Cancer and genomic instability Second problem set due

Feb. 28 Steward Exam 1 (covers Jan. 28 - Feb 125 lectures & readings)
March 3 Bhaumik

Concepts of mammalian genetic manipulation

March 6 Bhaumik Practical aspects of gene targeting,:  transgenesis and gene targeting of ES cells
March 10 Irvine

Signal transduction and Introduction to the Wnt pathway

March 13 Irvine Overview of Canonical Wnt Signaling
    Spring Break
March 24 Irvine

Genetic approaches toward identifying & ordering genes in a pathway

March 27 Irvine Morphogens and Extracellular Regulation of Wnt Signaling
March 31 Irvine Biochemical & Cell biological analysis of cytoplasmic & nuclear events in Wnt Signaling I
April 3 Gabriel Exam 2 (covers Jan. 24, plus March 3 - March 31 lectures & readings)
April 7 Irvine Biochemical & Cell biological analysis of cytoplasmic & nuclear events in Wnt Signaling II Third problem set handed out
April 10 Irvine Downstream of Wnt Signaling:  Transcriptional responses & Cellular Outcomes Third problem set due
April 14 Irvine Wnt Signaling Summary and Planner Cell Polarity
April 17 Steward Prenatal diagnosis/ Inherited diseases in humans
April 21 Steward

Gene therapy

April 24 Steward Personalized genomics
April 28 Gabriel

Transposons and Cancer

May 1 Gabriel An interesting genetic disease
May 5 Irvine Exam 3 (covers April 7 - May 1 lectures & readings)

last updated 2/13/2008