Faculty spacer Courses spacer Undergraduate Studies spacerUndergraduate Research spacer Graduate spacer Seminars spacer Links
Molecular Pathways and Signal Transduction 694:411
Fall

TTh5
Tuesdays and Thurs,
3:20-4:40 PM
Nelson A237, Busch

Syllabus

  Name Phone Office Hours Office
Co-Coordinator:
 Dr. Fumio Matsumura 445-2838 By appointment A321 Nelson
Co-Coordinator:
 Dr. Abram Gabriel 235-5097 By appointment 306 CABM
Dr. Steve Anderson 235-5022 By appointment 305 CABM
Dr. Steve Brill 235-4197 By appointment 304 CABM
       
Description
This course is a combination of lectures and discussion of current research areas of advanced molecular and structural biology: transcription, posttranscriptional regulation, cell cycle, neurobiology, macromolecular recognition, molecular virology.
Class # Topic Instructor Handouts
1 Introduction to the course Dr. Matsumura  
Topic 1: Transposition
 Dr. Gabriel  
2 Retrotransposon Replication Strategies  

Blemont (2006)
Han (2005)
Kazazian (2004)
Makalowski (2003)
Katz (1994)
Spector (2007)
3 Reverse Transcription

Lansman (1985)
Daniels (1990)
Tarlinton (2006)
4 Transposon Integration I  

Ramsey (1993)
Diamond (2004)
5 Transposon Integration II   He (2008)
6 LINEs & SINEs & Processed Pseudogenes   Garcia-Perez (2007)
Ovchinnikov (2002)
7 Exam I (Covers Lectures 1-6)    
Topic 2: Genomics, molecular pathways and Human evolution
Dr. Anderson  
8 Human genome, mutations and evolution

Balter (2005b)
Dennis (2005)
Check (2005)
Hein (2004)
Shreeve (2006)
Gross (2007)
Pew (2007)
Ledford (2007)
Lalueza-Fox (2007)
Culotta (2008)
9 Meiosis, recombination and haplotypes  

Golstein (2005)
Olson (2002)
Phimister (2005)
Przeworski (2005)
Pennisi (2005)
10 Genes that make us human I  

Lai (2001)
Varga-Khadem optional
Enard (2002)
Marcus & Fisher (2003)
Trinkhaus (2007)
11 Genes that make us human II  

Hill & Walsh (2005)
Pennisi (2006)
Balter (2005)
Hawks (2008)
Hedlund (2007)
12 Aging  

Mair (2008)
13 Exam II (Covers Lectures 8-12)    
Topic 3: Cell cycle I-G1/S transition
 Dr. Brill  
14 Genetic analysis of the cell cycle  
15

Biochemical analysis of the cell cycle

    
16

Signal transduction and the transition from G1 to S-phase

    
17 Control of DNA replication    
18 Checkpoint arrest of the cell cycle    
19 Exam III (Covers Lectures 14-18)  
Topic 4:Cell Cycle II-G2/M transition
 Dr. Matsumura
20

Maturation-Promoting Factor (MPF)

   Review
21

cdc2 Kinase

   Lohka (1998)
22 M-Phase Cycllin   Murray
Nigg
Heald
23 Regulation of MPF-Phosphorylation   Gould
24 Regulation of MPF-Proteolysis  
25 Downstream Events I (nuclear lamin)    
26 Downstream Events II (Chromosome segregation)   Holloway
27 Downstream Events III (cytokinesis)   Uhlmann
Peters
Shugo-Nasmyth
28 Exam IV (Covers Lectures 22-28)    
Exams are open-book, essay type questions.  Grades will be determined by Exam 1 (20%), 2 (20%), 3 (20%), 4 (32%) and class participation in discussion (8%).