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Molecular Pathways and Signal Transduction 694:411
Fall 2007

TTh5
Tuesdays and Thurs,
3:20-4:40 PM
Nelson A237, Busch

  Name Phone Office Hours Office
Co-Coordinator:
 Dr. Fumio Matsumura 445-2838 By appointment A321 Nelson
Co-Coordinator:
 Dr. Abram Gabriel 235-5097 By appointment 306 CABM
Dr. Steve Anderson 235-5022 By appointment 305 CABM
Dr. Steve Brill 235-4197 By appointment 304 CABM
       
# Day Date Topic Instructor Handouts
1 Tues. Sept. 4 Introduction to the course Dr. Matsumura  
Topic 1: Genomics, molecular pathways and Human evolution
Dr. Anderson  
2 Thurs Sept. 6 Human genome, mutations and evolution Lecture

Balter (2005b)
Dennis (2005)
Check (2005)
Hein (2004)
Shreeve (2006)
Gross (2007)
Pew (2007)
Ledford (2007)
3 Tues. Sept. 11 Meiosis, recombination and haplotypes Lecture

Golstein (2005)
Olson (2002)
Phimister (2005)
Przeworski (2005)
Pennisi (2005)
4 Thurs Sept. 13 Genes that make us human I Lecture

Lai (2001)
Varga-Khadem (2005)
Enard (2002)
Marcus & Fisher (2003)

5 Tues. Sept. 18 Genes that make us human II Lecture Hill & Walsh (2005)
Pennisi (2006)
Balter (2005)
6 Thurs. Sept 20 Aging Lecture Sinclair (2005)
7 Tues. Sept. 25 Exam I (Covers Lectures 1-6)    
Topic 2: Transposition
 Dr. Gabriel  
8 Thurs. Sept 27 Retrotransposon Replication Strategies Lecture
Slides 1-18
Slides 19-36
Slides 37-56
 Blemont (2006)
Han (2005)
Kazzazlan (2004)
Makalowski (2003)
Katz (1994)
9 Tues. Oct. 2 Reverse Transcription Lecture Ramsey (1993)
10 Thurs. Oct. 4 Transposon Integration I Lecture Kaiser (2007)
Dewannieuz (2003)
11 Tues. Oct. 9 Transposon Integration II Lecture Dai (2007)
Gai (1998)
Zhu (2003)
12 Thurs. Oct. 11 LINEs & SINEs & Processed Pseudogenes Lecture Salama (2004)
Dupuy (2005)
13 Tues. Oct. 16 Exam II (Covers Lectures 8-12)    
Topic 3: Cell Cycle II-G2/M transition
 Dr. Matsumura Lecture Figures (ppt)
14 Thurs. Oct. 18 Maturation-Promoting Factor (MPF) Lecture Lecture Fig 2 ppt
15 Tues Oct. 23 cdc2 Kinase Lecture Movie 1
16 Tues. Oct. 25 M-phase Cyclin Lecture Movie 2
17 Tues. Oct. 30 Regulation of MPF-Phosphorylation Lecture Movie 3
18 Thurs. Nov 1 Regulation of MPF-Proteolysis Lecture  
19 Tues. Nov. 6 Downstream Events I (nuclear lamin) Lecture
20 Thurs. Nov. 8 Downstream Events II (Chromosome segregation) Lecture  
21 Tues. Nov. 13 Downstream Events III (cytokinesis) Lecture Nasmyth.pdf
Topic 4: Cell cycle I-G1/S transition
 Dr. Brill
22 Thurs. Nov. 15 Genetic analysis of the cell cycle Lecture  
23 Tues. Nov. 20 Exam III (Covers Lectures 14-21) Lecture  
  Thurs Nov. 22 No Class - Thanksgiving Lecture  
24 Tues. Nov. 27 Biochemical analysis of the cell cycle Lecture  
25 Thurs Nov. 29 Signal transduction and the transition from G1 to S-phase Lecture  
27 Tues. Dec. 4 Control of DNA replication    
28 Thurs. Dec. 6 Checkpoint arrest of the cell cycle    
29 Tues. Dec. 11 Exam IV (Covers Lectures 22-28)    
Exams are open-book, essay type questions.  Grades will be determined by Exam 1 (20%), 2 (20%), 3 (32%), 4 (20%) and class participation in discussion (8%).