Molecular Biology and Biochemistry

#	Day	Date	Topic (links to lecture handouts)	Instructor	Chapter in Watson et al.
1	Tues.	Jan. 22	Structures of DNA and RNA (pdf)	Dr. Brill	6: p97-111; 1: p19-31; 7 p129-136
2	Fri.	Jan. 25	Bacterial DNA Replication I (2/p.pdf) (1/p.pdf)		8: p181-194; 4: p64-66
3	Tues.	Jan. 29	Bacterial DNA Replication II (2/p.pdf) (full.pdf)		8: p194-223
4	Fri.	Feb. 1	Eukaryotic DNA Replication I (2/p.pdf) (1/p.pdf)		8: p 224-233
5	Tues.	Feb. 5	Eukaryotic DNA Replication II (2/p.pdf) (1/p.pdf)		7: p151-165; 6: p111-122
	Fri.	Feb. 8	Exam I (Covers Lectures 1-5) Exam seating See exam rules below	Results	2008 Exam 1 answers
6	Tues.	Feb. 12	Recombinant DNA I (1/p.pdf) (2/p.pdf) Outline	Dr. Gabriel	Watson 20 Glossary Exam
7	Fri.	Feb. 15	Recombinant DNA II		Watson 20
8	Tues.	Feb. 19	DNA Mutability (1/p.pdf) (2/p.pdf) Outline Terms		Watson 9
9	Fri.	Feb. 22	DNA Repair (1/p.pdf) (2/p.pdf) Outline		Watson 9, 10
10	Tues.	Feb. 26	DNA Recombination (1/p.pdf) (2/p.pdf) Outline		Watson 10, 11
11	Fri.	Feb. 29	DNA Transposition (1/p.pdf) (2/p.pdf) Outline		Watson 11
	Mon.	Mar. 3	Help Session, 2-4:00PM CABM Rm 308
	Tues.	Mar. 4	Exam II (Covers Lectures 6-11) Exam seating	Results	Old Exam Answers
12	Fri	Mar. 7	Transcription -Basic Processes	Dr. Vershon	Watson 12 (pp 347-363) ‡
13	Tues.	Mar. 11	Transcriptional Regulation in Bacteria		Watson 16 (pp 480-527); 5 (pp 81-91) ‡
14	Fri	Mar. 14	Transcriptional Regulation in Bacteria		Watson 16 (pp 480-527) ‡
	Tues.	Mar. 18	Spring Break
	Fri.	Mar. 21	Spring Break
15	Tues.	Mar. 25	Transcription in Eukaryotes		Watson 7 (pp 151-175) 12 (pp 363-377) ‡
16	Fri.	Mar. 28	Transcriptional Regulation in Eukaryotes Pick up Take-Home Exam Problem		Watson 17 (529-563) ‡
17	Tues.	Apr. 1	Transcriptional Regulation in Eukaryotes		Watson 17 (529-563) ‡
18	Fri.	Apr. 4	Transcriptional Regulation in Eukaryotes Help session 2-4 PM Waksman Rm 1001		‡
	Mon	Apr. 7	Help session 2-4 PM Waksman Auditorium
	Tues.	Apr. 8	Exam III (Covers Lectures 12-18)	Results	Old Exams Exam III Answers
19	Fri.	Apr. 11	Post-transcriptional Control: Splicing & Polyadenylation	Dr. Gunderson	Watson 13‡
20	Tues	Apr. 15	Post-transcriptional Control: Splicing & Polyadenylation (cont.)		Watson 13‡
21	Fri.	Apr. 18	Post-transcriptional Control: Splicing & Polyadenylation (cont.)		Watson 13‡
22	Tues.	Apr. 22	RNA World, Ribozymes, RNA Splicing		Watson 13‡
23	Fri.	Apr. 25	Control of mRNA Translation, Stability, Localization		Watson 14
24	Tues.	Apr. 29	Translation: Bacterial & Eukaryotic		Watson 14, 15 ‡
	Fri	May 2	No Class!!!		See here for what material will not be covered
	Mon.	May 12	Review Session 6-7:30 PM, Nelson A237
	Wed.	May 14	(4:00-6:00 PM) SEC111 Exam IV (Covers Lectures 19-25)	Results	Answer sheet Exams can be picked up at Dr. Vershon's office starting Tues, 5/20

Required Text:
Watson, J.D., et al. (2004) Molecular Biology of the Gene, 5th Ed., Benjamin Cummings.
‡Supplementary readings will be provided.

Usefull On-line Texts:
Biochemistry, 5th edition by Berg, Tymoczko and Stryer
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=stryer.TOC&depth=2

Genomes, 2nd edition by Brown
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=genomes.TOC&depth=2

An Introduction to Genetic Analysis by Griffiths, Miller, Suzuki, Lewontin, and Gelbart
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=iga.TOC

Modern Genetic Analysis by Griffiths, Gelbart, Miller, and Lewontin
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mga.TOC

Molecular Biology of the Cell, 4th edition by Alberts, Johnson, Lewis, Raff, Roberts, and Walter
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.TOC&depth=2

Molecular Cell Biology by Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.TOC

Molecular Biology and Biochemistry 694:407-408 is offered as the primary lecture courses for undergraduate students in the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in a contemporary, comprehensive two-semester course in these rapidly developing disciplines. Biochemistry 115:511-512 mainly serves graduate students in Graduate Programs other than Molecular Biosciences. Students in the Molecular Biosciences Graduate Program should take 115:501-502.

The Lecturers can be consulted for additional assistance by appointment or during office hours:

Instructor	Time	Place	Phone No.	E-Mail
Dr. Steve Brill	By appointment	304 CABM	235-4197	brill@cabm.rutgers
Dr. Abram Gabriel	By appointment	308 CABM	235-5097	gabriel@cabm.rutgers
Dr. Sam Gunderson	By appointment	A322 Nelson	445-1016	gunderson@biology.rutgers
Dr. Andrew K. Vershon	By appointment, Thurs 3-5	233 Waksman	445-2905	vershon@waksman.rutgers

Hourly examinations will be given at the end of each series of lectures on the indicated dates during regular class hours; the first three will be given in assigned seats in the SERC 111 classroom. The fourth hourly examination is scheduled for Weds. May 14 from 4:00 noon to 5:30 PM, during the final exam period, in a room to be announced -- there will be no cumulative final exam. All exams are closed book. Students will not be permitted to have bags, phones or papers by their seats. Students are expected to follow the Rutgers Academic Integrity Code. Students caught cheating will get a zero for the exam and the Dean's office will be notified. All exams will be graded promptly and the grades will be posted on Rutgers Gradebook. All four examinations will be averaged and weighted equally in assigning final grades.

Requests for corrections of exam grading will only be considered within a week after exam papers have been returned. Students who are unable to take an hourly exam at the scheduled time because of compelling reasons supported by documentation, such as a note from their Physician, may be permitted to take a make-up examination. It should be realized that Professors will have discretion in penalizing make-up tests. Arrangements should be made with Prof. Vershon.

Last modified 8/8/07. Contact Dr. Vershon if you are having problems with the site