| # |
Day |
Date |
Topic (links to lecture handouts) |
Instructor |
Chapter in Watson et al. Ed 5 |
Chapter in Watson et al. Ed 6 |
| 1 |
Tues. |
Jan. 19 |
Structures of DNA and RNA |
Dr. Brill |
6: 97-111;
1: 19-31;
6: 129-136 |
6: 101-116;
1: 19-32;
6: 117-126
|
| 2 |
Fri. |
Jan. 22 |
Bacterial DNA Replication I |
|
Ch8; 4:64-67 |
Ch8: 4:66-69 |
| 3 |
Tues. |
Jan. 26 |
Bacterial DNA Replication II |
|
Ch8 |
Ch8 |
| 4 |
Fri. |
Jan. 29 |
Eukaryotic DNA Replication I |
|
Ch8 |
Ch8 |
| 5 |
Tues. |
Feb. 2 |
Eukaryotic DNA Replication II |
|
7: 151-165;
6: 111-122 |
7: 157-174;
6: 117-126 |
| |
Fri. |
Feb. 5 |
Exam I (Covers Lectures 1-5)
See exam rules below |
|
|
|
| 6 |
Tues. |
Feb. 9 |
Recombinant DNA I (2/p.pdf) (1/p.pdf) Outline |
Dr. Brill |
18: pp 575-576;
20: pp 644-667;
21: pp 682-692
|
19: 661-662;
21: 739-764;
22: 783-794 |
| 7 |
Fri. |
Feb. 12 |
Recombinant DNA II (2/p.pdf) (1/p.pdf) |
|
Watson 20 |
|
| 8 |
Tues. |
Feb. 16 |
DNA Mutability, Outline Terms |
Dr. Gabriel |
1: pp 15-17;
6: pp 98-102;
8, pp 184-192;
9, pp. 236-238. |
1: pp 15-17;
6: pp 102-107;
8, pp 198-209;
9, pp. 258-260. |
| 9 |
Fri. |
Feb. 19 |
DNA Repair |
|
9: pp 235-257 |
9: pp 257-281 |
| 10 |
Tues. |
Feb. 23 |
DNA Recombination
|
|
1: pp 6-13;
9: pp 253-254;
10: pp 259-284;
10: pp 288-291;
11: pp 337-341. |
1: 6-13;
9: 275-278;
10: 283-310;
10: 314-317;
11: 365-369. |
| 11 |
Fri. |
Feb. 26 |
DNA Transposition
|
|
11: 293-295;
11: 305-307;
11: 310-330;
11: 334-337
|
11: 319-321;
11: 331-359;
11: 362-365. |
| |
Tues. |
Mar. 2 |
Exam II (Covers Lectures 6-11)
|
|
|
|
| 12 |
Fri |
Mar. 5 |
Transcription -Basic Processes
|
Dr. Vershon |
12: 344-363 |
12: 372-396 |
| 13 |
Tues. |
Mar. 9 |
Transcriptional Regulation in Bacteria |
|
16: 480-527
5: 81-91 |
16: 542-587
5: 82-94
|
| 14 |
Fri |
Mar. 12 |
Transcriptional Regulation in Bacteria |
|
16: 480-527
|
16: 542-587
18: 633-640 |
| |
Tues. |
Mar. 16 |
Spring Break |
|
|
|
|
Fri. |
Mar. 19 |
Spring Break |
|
|
|
| 15 |
Tues. |
Mar. 23 |
Transcription in Eukaryotes |
|
7: 151-175
12: 363-377 |
7: 157-187
12: 396-414
|
| 16 |
Fri. |
Mar. 26 |
Transcriptional Regulation in Eukaryotes
|
|
17: 529-563 |
17:589-632 |
| 17 |
Tues. |
Mar. 30 |
Transcriptional Regulation in Eukaryotes |
|
17: 529-563 |
17: 589-632 |
| 18 |
Fri. |
Apr. 2 |
Transcriptional Regulation in Eukaryotes
|
|
|
|
| |
Tues. |
Apr. 6 |
Exam III (Covers Lectures 12-18) |
|
|
|
| 19 |
Fri. |
Apr. 10 |
Post-transcriptional Control: Splicing & Polyadenylation |
Dr. Gunderson |
13‡ |
13, 18‡ |
| 20 |
Tues |
Apr. 14 |
Post-transcriptional Control: Splicing & Polyadenylation (cont.) |
|
13‡ |
13, 18‡ |
| 21 |
Fri. |
Apr. 17 |
Post-transcriptional Control: Splicing & Polyadenylation (cont.) |
|
13‡ |
13, 18‡ |
| 22 |
Tues. |
Apr. 21 |
RNA World, Ribozymes, RNA Splicing |
|
13‡ |
13, 18‡ |
| 23 |
Fri. |
Apr. 24 |
Control of mRNA Translation, Stability, Localization |
|
14 |
14 |
| 24 |
Tues. |
Apr. 28 |
Translation: Bacterial & Eukaryotic |
|
14, 15 ‡ |
14, 15 ‡ |
| 25 |
Fri |
May 1 |
Translation: Bacterial & Eukaryotic |
|
|
|
| |
|
|
Review Session |
|
|
|
|
Thurs |
May 7 |
Exam IV (Covers Lectures 19-25) 12:00 PM-3:00 PM |
|
|
|
Required Text:
Watson, J.D., et al. (2008) Molecular Biology of the Gene, 6th Ed., Benjamin Cummings.
‡Supplementary readings will be provided.
Usefull On-line Texts:
Biochemistry, 5th edition by Berg, Tymoczko and Stryer
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=stryer.TOC&depth=2
Genomes, 2nd edition by Brown
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=genomes.TOC&depth=2
An Introduction to Genetic Analysis by Griffiths, Miller, Suzuki, Lewontin, and Gelbart
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=iga.TOC
Modern Genetic Analysis by Griffiths, Gelbart, Miller, and Lewontin
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mga.TOC
Molecular Biology of the Cell, 4th edition by Alberts, Johnson, Lewis, Raff, Roberts, and Walter
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.TOC&depth=2
Molecular Cell Biology by Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.TOC
Molecular Biology and Biochemistry 694:407-408 is offered as the primary lecture courses for undergraduate students in the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in a contemporary, comprehensive two-semester course in these rapidly developing disciplines. Biochemistry 115:511-512 mainly serves graduate students in Graduate Programs other than Molecular Biosciences. Students in the Molecular Biosciences Graduate Program should take 115:501-502.
The Lecturers can be consulted for additional assistance by appointment or during office hours:
| Instructor |
Time |
Place |
Phone No. |
E-Mail |
| Dr. Steve Brill |
By appointment |
304 CABM |
235-4197 |
brill@cabm.rutgers |
| Dr. Abram Gabriel |
By appointment |
308 CABM |
235-5097 |
gabriel@cabm.rutgers |
| Dr. Sam Gunderson |
By appointment |
A322 Nelson |
445-1016 |
gunderson@biology.rutgers |
| Dr. Thomas Kusch |
|
|
445-6895 |
|
Hourly examinations will be given at the end of each series of lectures on the indicated dates during regular class hours; the first three will be given in assigned seats in the SERC 111 classroom. The fourth hourly examination is scheduled for XXX. May XX from XX noon to XX PM, during the final exam period, in a room to be announced -- there will be no cumulative final exam. All exams are closed book. Students will not be permitted to have bags, phones or papers by their seats. Students are expected to follow the Rutgers Academic Integrity Code. Students caught cheating will get a zero for the exam and the Dean's office will be notified. All four examinations will be averaged and weighted equally in assigning final grades.
Requests for corrections of exam grading will only be considered within a week after exam papers have been returned. Students who are unable to take an hourly exam at the scheduled time because of compelling reasons supported by documentation, such as a note from their Physician, may be permitted to take a make-up examination. It should be realized that Professors will have discretion in penalizing make-up tests. Arrangements should be made with Prof. Vershon.
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