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Molecular Biology & Biochemistry 694:408/115:512 Spring 2008

Tuesdays and Fridays,
10:20-11:40 AM
SEC111, Busch

  Name Phone Office Hours Office
Coordinator:
Dr. Andrew Vershon 445-2905 By appt. 234 Waksman
Instructors:
Dr. Abram Gabriel 235-5097 By appt. 306 CABM
Dr. Sam Gunderson 445-1016 By appt. A322 Nelson
Dr. Steve Brill 235-4197 By appt. 304 CABM

Notices: The links to this site are password protected. Please check your eden account for the username and password.

The distribution of grades for the course can be found here.

# Day Date Topic (links to lecture handouts) Instructor Chapter in Watson et al.
1 Tues. Jan. 22 Structures of DNA and RNA (pdf) Dr. Brill 6: p97-111; 1: p19-31; 7 p129-136
2 Fri. Jan. 25 Bacterial DNA Replication I (2/p.pdf) (1/p.pdf)   8: p181-194; 4: p64-66
3 Tues. Jan. 29 Bacterial DNA Replication II (2/p.pdf) (full.pdf)   8: p194-223
4 Fri. Feb. 1 Eukaryotic DNA Replication I (2/p.pdf) (1/p.pdf)   8: p 224-233
5 Tues. Feb. 5 Eukaryotic DNA Replication II (2/p.pdf) (1/p.pdf)   7: p151-165; 6: p111-122
  Fri. Feb. 8 Exam I (Covers Lectures 1-5) Exam seating
See exam rules below
Results

2008 Exam 1 answers

6 Tues. Feb. 12 Recombinant DNA I (1/p.pdf) (2/p.pdf) Outline Dr. Gabriel Watson 20 Glossary Exam
7 Fri. Feb. 15 Recombinant DNA II   Watson 20
8 Tues. Feb. 19 DNA Mutability (1/p.pdf) (2/p.pdf) Outline Terms   Watson 9
9 Fri. Feb. 22 DNA Repair (1/p.pdf) (2/p.pdf) Outline   Watson 9, 10
10 Tues. Feb. 26 DNA Recombination (1/p.pdf) (2/p.pdf) Outline
  Watson 10, 11
11 Fri. Feb. 29 DNA Transposition (1/p.pdf) (2/p.pdf) Outline
  Watson 11
  Mon. Mar. 3 Help Session, 2-4:00PM CABM Rm 308    
  Tues. Mar. 4 Exam II (Covers Lectures 6-11) Exam seating

Results Old Exam Answers
12 Fri Mar. 7 Transcription -Basic Processes
Dr. Vershon Watson 12 (pp 347-363) ‡
13 Tues. Mar. 11 Transcriptional Regulation in Bacteria   Watson 16 (pp 480-527); 5 (pp 81-91) ‡
14 Fri Mar. 14 Transcriptional Regulation in Bacteria   Watson 16 (pp 480-527) ‡
  Tues. Mar. 18 Spring Break    
Fri. Mar. 21 Spring Break
15 Tues. Mar. 25 Transcription in Eukaryotes   Watson 7 (pp 151-175) 12 (pp 363-377) ‡
16 Fri. Mar. 28 Transcriptional Regulation in Eukaryotes
Pick up Take-Home Exam Problem
  Watson 17 (529-563) ‡
17 Tues. Apr. 1 Transcriptional Regulation in Eukaryotes   Watson 17 (529-563) ‡
18 Fri. Apr. 4

Transcriptional Regulation in Eukaryotes
Help session 2-4 PM Waksman Rm 1001

 
  Mon Apr. 7 Help session 2-4 PM Waksman Auditorium    
  Tues. Apr. 8 Exam III (Covers Lectures 12-18) Results Old Exams Exam III Answers
19 Fri. Apr. 11 Post-transcriptional Control: Splicing & Polyadenylation Dr. Gunderson Watson 13‡
20 Tues Apr. 15

Post-transcriptional Control: Splicing & Polyadenylation (cont.)

  Watson 13‡
21 Fri. Apr. 18 Post-transcriptional Control: Splicing & Polyadenylation (cont.)   Watson 13‡
22 Tues. Apr. 22

RNA World, Ribozymes, RNA Splicing

  Watson 13‡
23 Fri. Apr. 25

Control of mRNA Translation, Stability, Localization

  Watson 14
24 Tues. Apr. 29

Translation: Bacterial & Eukaryotic

  Watson 14, 15 ‡
  Fri May 2 No Class!!!   See here for what material will not be covered
  Mon. May 12 Review Session 6-7:30 PM, Nelson A237    
Wed. May 14 (4:00-6:00 PM) SEC111
Exam IV (Covers Lectures 19-25)
Results Answer sheet
Exams can be picked up at Dr. Vershon's office starting Tues, 5/20

Required Text:
Watson, J.D., et al. (2004) Molecular Biology of the Gene, 5th Ed., Benjamin Cummings.
‡Supplementary readings will be provided.

Usefull On-line Texts:
Biochemistry, 5th edition by Berg, Tymoczko and Stryer
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=stryer.TOC&depth=2

Genomes, 2nd edition by Brown
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=genomes.TOC&depth=2

An Introduction to Genetic Analysis by Griffiths, Miller, Suzuki, Lewontin, and Gelbart
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=iga.TOC

Modern Genetic Analysis by Griffiths, Gelbart, Miller, and Lewontin
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mga.TOC

Molecular Biology of the Cell, 4th edition by Alberts, Johnson, Lewis, Raff, Roberts, and Walter
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mboc4.TOC&depth=2

Molecular Cell Biology by Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mcb.TOC

Molecular Biology and Biochemistry 694:407-408 is offered as the primary lecture courses for undergraduate students in the Molecular Biology and Biochemistry major, as well as for non-majors who wish to enroll in a contemporary, comprehensive two-semester course in these rapidly developing disciplines. Biochemistry 115:511-512 mainly serves graduate students in Graduate Programs other than Molecular Biosciences. Students in the Molecular Biosciences Graduate Program should take 115:501-502.

The Lecturers can be consulted for additional assistance by appointment or during office hours:

Instructor Time Place Phone No. E-Mail
Dr. Steve Brill By appointment 304 CABM 235-4197 brill@cabm.rutgers
Dr. Abram Gabriel By appointment 308 CABM 235-5097 gabriel@cabm.rutgers
Dr. Sam Gunderson By appointment A322 Nelson 445-1016 gunderson@biology.rutgers
Dr. Andrew K. Vershon By appointment, Thurs 3-5 233 Waksman 445-2905 vershon@waksman.rutgers

Hourly examinations will be given at the end of each series of lectures on the indicated dates during regular class hours; the first three will be given in assigned seats in the SERC 111 classroom. The fourth hourly examination is scheduled for Weds. May 14 from 4:00 noon to 5:30 PM, during the final exam period, in a room to be announced -- there will be no cumulative final exam.  All exams are closed book. Students will not be permitted to have bags, phones or papers by their seats. Students are expected to follow the Rutgers Academic Integrity Code. Students caught cheating will get a zero for the exam and the Dean's office will be notified. All exams will be graded promptly and the grades will be posted on Rutgers Gradebook.  All four examinations will be averaged and weighted equally in assigning final grades.

Requests for corrections of exam grading will only be considered within a week after exam papers have been returned.  Students who are unable to take an hourly exam at the scheduled time because of compelling reasons supported by documentation, such as a note from their Physician, may be permitted to take a make-up examination. It should be realized that Professors will have discretion in penalizing make-up tests. Arrangements should be made with Prof. Vershon.

Last modified 8/8/07. Contact Dr. Vershon if you are having problems with the site